Endocrine Abstracts

Introduction: The simultaneous occurrence in the same patient of more than one endocrinological condition is rare and was described in the multiple endocrine neoplasia (MEN). Here, we report a patient with an unusual combination of primary-hyperparathyroidism, papillary thyroid microcarcinoma, primary-hyperaldosteronism and ACTH-independent Cushing’s syndrome.Case description: A 54-year-old women with a primary-hyperparathyroidism was admitted to ou...

Adrenocortical carcinoma (ACC) is a rare malignancy, accounting for 0.02% of all annual cancer. The majority of these tumors are benign, non-functioning adenomas that are incidentally discovered on abdominal image studies. Others are functional adenomas secreting cortisol, aldosterone, or less commonly androgens or estrogens. Pure androgen-secreting adrenal tumors are very rare.Case report: A 34-year-old female patient presented with pain in the left upp...

Introduction: The metabolic stressor, hypoglycemia, elicits integrated counterregulatory responses, including activation of the hypothalamic–pituitary–adrenal axis. However, it is suggested that recurring insulin-induced hypoglycemia can impair this counter-regulation. Here we report three cases of patients with isulinoma and corticotroph deficiency.Case reports: The first case, 38-year-old man was referred because of recurrent episode...

Introduction: Neuroendocrine tumors may develop in almost any organ. These types of tumors may present with giant and asymptomatic mass. We describe a case of a large non functional neuroendocrine tumor reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia in 2016.Presentation of case: A 28 years old male presented with asthenia, gastric heaviness and epigastric pain. Further computerized tomography, a large ...

Introduction: Multiple autoimmune syndrome (MAS) is a rare condition, first described by Humbert and Dupond in 1988 and characterised by three or more autoimmune disorders in the same individual.Case description: Here we present a case of 14-year-old female patient diagnosed with ocular myasthenia gravis. The diagnosis of Graves’ disease was suspected on the basis of hyperthyroidism symptoms and confirmed by undetectable TSH level (<0.01 mUI/l) ...

Introduction: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. A female appearance patient with secondary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. We here report a case of a 16- year-old girl with secondary amenorrhea and 46 XY karyotype after bone marrow transplantation (BM...

Introduction: Graves’ disease GD is an autoimmune disease, which can manifest with a variety of extrathyroidal clinical syndromes. Though quite rare, this disease can also manifest with lymphoid hyperplasia.Case report: Two cases are reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia from 2006 to 2016 associated GD with lymphoid hyperplasia reaction. The first case was a 32 years old male with history...

Introduction: Autoimmune thyroid diseases are known to be associated with oxidative stress.Objectives: We studied the oxidative profiles in plasma and thyroid tissue of 82 patients having Graves’ disease (GD) or Hashimoto thyroiditis (HT) or hashitoxicosis (HTX) vs 65 healthy controls in order to evaluate the antioxidant enzymes’ activity and the lipid peroxidation.Results: The lipid peroxidation was objected with a signi...

Introduction: Subclinical Cushing’s syndrome refers to autonomous cortisol secretion in patients who do not have the typical signs and symptoms of hypercortisolism. This study was undertaken to describe clinical, biological and radiological features of this disease and to evaluate the clinical outcome after surgical and medical treatment.Methods: Retrospective study conducted over a period of 12 years and including 17 patients hospitalised in our de...

Introduction: Diabetic foot infection (DFI) is a major public health problem, both for its morbid clinical consequences mainly ulcers and the economic social cost due to repeated hospitalisations and the high rate of amputation.Objectives: Analyse the clinical presentation of DFI, study risk factors of developing this infection and describe the therapeutic management.Materials and methods: Retrospective study spread over 8 years ol...